Karlie has extensive experience in teaching across many platforms, educational areas and levels. She is advocate for one on one tutoring, particuarly for those who struggle with the traditional format of school.  She has a decades worth of experience in providing one on one tutoring services to primary, high school and undergraduate students in mathematics and science.

Currently, Karlie is the co-coordinator of an introductory astronomy course titled Astronomy and Space at the Australian National University. Part of the course explores the rich histories of Aboriginal and Torres Strait Islander peoples, notable Indigenous astronomical observations, the various applications of such observations and how Indigenous peoples care for country, including sky country. Other topics covered in the course include space travel and colonisation, our solar neighbourhood and space law and space medicine. The course is available to students at the ANU and world-wide on the MOOC website.

Karlie has appeared as a guest lecture for many universities including University of Canberra, University of Southern Queensland, Monash University, and University of Newcastle where she regularly presents on topics including Indigenous knowledge systems and science communication.