Karlie has extensive experience in teaching across many platforms, educational areas and levels. She is advocate for one on one tutoring, particuarly for those who struggle with the traditional format of school. 

Karlie is the co-coordinator of an introductory astronomy course titled Astronomy and Space at the Australian National University. Part of the course explores the rich histories of Aboriginal and Torres Strait Islander peoples, notable Indigenous astronomical observations, the various applications of such observations and how Indigenous peoples care for country, including sky country. 

Karlie has appeared as a guest lecture for many universities including University of Canberra, University of Southern Queensland, Monash University, and University of Newcastle where she presents on topics including Indigenous knowledge systems and science communication.